Metabolites and lipids directly reflect biological function and disease state. As the molecular layer closest to phenotype, they capture host and microbial metabolic activity underlying health and disease. Our metabolomics and lipidomics services for pathway specific assays deliver the sensitivity and quantitative precision needed to address focused biological, translational, and clinical questions.
biocrates’ specialized metabolomics and lipidomics services focus on defined biological pathways and analytically challenging metabolite classes, delivering high sensitivity and quantitative accuracy beyond broad profiling approaches.
These targeted services are well suited for focused biological, translational, and clinical research questions where pathway‑level resolution and quantitative precision are required. They enable confident interrogation of specific metabolic processes that are difficult to assess with untargeted profiling alone.
All services are based on fully calibrated, quality‑controlled workflows that combine pathway‑specific assay design with expert in‑house execution. biocrates provides end‑to‑end scientific support, from study design through data delivery, ensuring reproducible, decision‑ready metabolomics and lipidomics data.
Quantitative profiling of steroid hormone signaling.
Quantification of primary and secondary bile acids.
Quantifying key regulators of cholesterol metabolism.
The ideal triad for studying metabolic health and the microbiome.
Three pathways, one solution.
Understanding energy metabolism and mitochondrial function.
Ultra-high sensitivity for challenging metabolites enables reliable analysis of critical signaling molecules and pathway markers.
Pathway- and class specific assay design ensures high quality data for your metabolites of interest for hypothesis-driven, mechanistic and translational studies.
Standardized, reproducible workflow with absolute quantitative output supports cross study comparability, longitudinal designs, and robust statistical evaluation.
Advanced data interpretation with pre-defined, disease-specific metabolism indicators (sums and ratios) enhances group comparison and biological understanding.
End-to-end scientific expert support, built on 20 years of metabolomics experience, guides you across the entire workflow.
1. Sample Preparation
Careful preparation of your samples with standardized protocols.
2. Measurement
LC-MS/MS measurement with optimized, validated methods.
3. Data Processing
Metabolite quantification and quality control.
4. Data Analysis
Statistical analysis and visualization.
5. Interpretation
Pathway analysis and biological interpretation.
M&L Service
Steroid hormones are key regulators of metabolism, cell growth, immune function, and electrolyte balance across health and disease. Derived from cholesterol and primarily produced in the adrenal glands and gonads, their tightly controlled regulation makes accurate quantification challenging across different biological contexts and species. biocrates Stero17 assay service is designed to comprehensively capture steroid hormone signaling with high analytical confidence.
This specialized service enables reliable, absolute quantification of 17 steroid hormones spanning all five major steroid classes, accurately covering their physiological concentration range. Supported by standardized, quality‑controlled workflows and end‑to‑end scientific expertise, the service delivers reproducible hormone profiles suitable for translational, pharmaceutical, and biomedical research – supporting mechanistic studies, biomarker discovery, and hormone‑related disease research from animal models to human samples.
M&L Service
Bile acids are produced in the liver and are best known to facilitate the absorption of dietary fats and fat-soluble vitamins. Beyond this, bile acids exert important signaling and regulatory functions via nuclear receptors such as the farnesoid X receptor (FXR). Since gut bacteria convert primary into secondary bile acids, they are essential to study the role of gut microbiota in health and disease.
The biocrates Bile Acids assay is the first standardized solution for the quantitation of 20 bile acids by liquid chromatography-mass spectrometry (LC-MS). This specialized assay offers a comprehensive panel of 20 primary and secondary bile acids, enabling functional understanding of the gut microbiome and liver-related disorders. All metabolites are fully calibrated and quantified using internal standards, ensuring outstanding accuracy and precision.
M&L Service
Oxysterols are potent signaling molecules involved in cholesterol homeostasis, inflammation, oxidative stress, and neurodegeneration, but occur at very low concentrations and are prone to autooxidation artefacts. biocrates Oxysterol assay profiling service is specifically designed to overcome these analytical challenges through optimized sample handling, rigorous quality control, and confident isomer‑specific separation using a highly sensitive LC‑MS/MS workflow.
This specialized service enables reliable quantification of free oxysterols and cholesterol‑derived intermediates across critical metabolic pathways. By delivering accurate and reproducible oxysterol profiles, the service supports mechanistic research, pharmacodynamic studies, and biomarker discovery in lipid metabolism, inflammation, and neurodegenerative disease research.
M&L Service
Short‑, branched- and medium‑chain fatty acids (SCFAs, BCFAs, and MCFAs) are key metabolites linking diet, gut microbiome activity, and host energy metabolism. As both energy substrates and signaling molecules, they play central roles in immune regulation, insulin sensitivity, and gut–brain and gut–immune axis communication. biocrates’ SCFA+ profiling service is designed to accurately capture these microbiome‑driven metabolic signals.
This specialized service enables reliable, quantitative profiling of short‑, branched‑, and medium‑chain fatty acids across relevant biological matrices. Through standardized, quality‑controlled LC‑MS workflows, optimized sample handling, and absolute quantification, the service delivers reproducible SCFA and MCFA profiles that support translational, pharmaceutical, and nutritional research focused on metabolism, inflammation, and microbiome–host interactions.
M&L Service
Tryptophan metabolism is a central regulator of immune responses, neurological function, and gut–host communication. Through the kynurenine, serotonin, and indole pathways, tryptophan‑derived metabolites act as key signaling molecules influencing inflammation, neurotransmission, and microbiome–host interactions. biocrates Tryptophan Metabolism assay profiling service is designed to comprehensively capture these tightly regulated pathways.
This specialized service enables reliable, quantitative profiling of pathway‑specific tryptophan metabolites and their biologically meaningful ratios. By delivering reproducible, absolute concentration data supported by expert scientific guidance, the service supports mechanistic research, biomarker discovery, and therapeutic development in oncology, neurodegeneration, immunology, and cardiometabolic disease.
M&L Service
Acylcarnitines serve as integrative markers of mitochondrial metabolism, beta‑oxidation, and energy homeostasis. biocrates’ acylcarnitine profiling service extends beyond standard clinical panels to include an expanded range of acylcarnitines relevant for aging, cardiovascular disease, neurodegeneration, and inborn errors of metabolism.
By delivering comprehensive, quantitative acylcarnitine profiles, the service enables exploration of metabolic flexibility, mitochondrial dysfunction, and disease‑associated energy imbalance across clinical and translational research settings.
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